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Palindromic rheumatism: a response to chloroquine
W Youssef1, A Yan, A S Russell
1Rheumatic Disease Unit, University of Alberta, Edmonton, Canada.
The Journal of Rheumatology
|January 1, 1991
Summary
Antimalarial therapy significantly reduced symptoms in patients with palindromic rheumatism. This treatment offers an effective option for managing this condition and preventing persistent arthritis.
Area of Science:
- Rheumatology
- Pharmacology
Background:
- Palindromic rheumatism is a rare condition characterized by recurrent attacks of arthritis.
- Understanding effective treatment options is crucial for patient management.
Purpose of the Study:
- To evaluate the efficacy of antimalarial therapy in patients with palindromic rheumatism.
- To assess the impact of treatment on symptom frequency and duration.
Main Methods:
- Retrospective review of 71 patients diagnosed with palindromic rheumatism.
- Analysis of treatment outcomes for patients receiving antimalarial therapy, specifically chloroquine.
Main Results:
- Forty-one of 51 patients on antimalarial therapy showed marked improvement, with a 77.5% reduction in attack frequency and a 63% reduction in duration.
- 16 patients developed persistent arthritis, including rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, and asymmetric seronegative arthropathy.
Conclusions:
- Chloroquine therapy demonstrates significant effectiveness in alleviating symptoms of palindromic rheumatism.
- Antimalarial treatment may play a role in preventing the progression to chronic arthritic conditions.