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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

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Published on: April 28, 2023

Copper deficiency myelopathy.

Stephan R Jaiser1, Gavin P Winston

  • 1Department of Neurology, Newcastle General Hospital, Westgate Road, Newcastle Upon Tyne, NE4 6BE, UK. stephan.jaiser@nuth.nhs.uk

Journal of Neurology
|March 17, 2010
PubMed
Summary
This summary is machine-generated.

Acquired copper deficiency can cause anemia and neutropenia, mimicking vitamin B12 deficiency. Early diagnosis and copper supplementation are crucial for neurological improvement.

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Area of Science:

  • Neurology
  • Hematology
  • Nutritional Science

Background:

  • Acquired copper deficiency is a rare cause of anemia and neutropenia.
  • Copper deficiency myelopathy (CDM) mimics subacute combined degeneration from vitamin B12 deficiency.
  • CDM is a treatable non-compressive myelopathy.

Purpose of the Study:

  • To review 55 case reports of Copper Deficiency Myelopathy (CDM).
  • To analyze demographics, etiology, clinical presentation, and treatment outcomes.
  • To discuss the pathophysiology of copper metabolism disorders.

Main Methods:

  • Literature review of 55 case reports.
  • Analysis of patient demographics, risk factors, and clinical findings.
  • Review of hematological, biochemical, and spinal imaging data.

Main Results:

  • CDM most commonly affects individuals in their fifth and sixth decades, with a higher incidence in women (3.6:1).
  • Risk factors include gastrointestinal surgery, zinc overload, and malabsorption.
  • Cytopenias (78%) and abnormal spinal MRI (47%) were common findings. Low serum copper and caeruloplasmin confirmed diagnosis.

Conclusions:

  • Copper deficiency myelopathy is a treatable neurological condition.
  • Early detection through risk factors, cytopenias, and biochemical tests is vital.
  • Copper supplementation and risk factor modification improve outcomes, but recovery may be partial.