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Updated: Jun 15, 2026

Differentiation and Characterization of Neural Progenitors and Neurons from Mouse Embryonic Stem Cells
Published on: May 15, 2020
Key players in the gene networks guiding ESCs toward mesoderm
Nadezda Omelyanchuk1, Irina A Orlovskaya, Ingrid U Schraufstatter
1Institute for Cytology and Genetics, 10 Lavrentieva, Novosibirsk 630090, Russian Federation.
Abstract:
Embryonic stem cells (ESCs) offer a powerful in vitro model to study mechanisms implicated in cell fate decision. Developmental pathways by which pluripotent ESCs become committed to specific lineages are reflected in dynamic changes of signaling and transcriptional programs. However, the mechanisms that govern the regulatory intracellular networks underlying lineage fate decisions and differentiation programs remain poorly understood and differ significantly in different species. In this review we analyze the current understanding of the signaling mechanisms and transcriptional regulation of differentiation of murine and human ESCs into the mesoderm.
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