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Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica
Li-Jie Zhang1, Chun-Tang Chiou, Jing-Jy Cheng
1National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China.
Journal of Natural Products
|March 18, 2010
Abstract
None:
Six new polyisoprenyl benzophenonoids, (+/-)-garcinialiptone A (1, 2), garcinialiptone B (3), (-)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1-6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).