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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Avidin-biotin technology in targeted therapy.

Hanna P Lesch1, Minna U Kaikkonen, Jere T Pikkarainen

  • 1University of Eastern Finland, A.I. Virtanen institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland.

Expert Opinion on Drug Delivery
|March 18, 2010
PubMed
Summary

Avidin-biotin technology enables targeted drug delivery by concentrating therapeutic agents at disease sites, reducing side effects. This versatile system also facilitates gene therapy vector targeting and gene delivery.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Delivery Systems

Background:

  • Drug targeting aims to enhance therapeutic concentration at disease sites while sparing healthy tissues.
  • Conventional treatments often cause side effects due to their broad action.
  • Targeting strategies can improve drug efficacy and patient outcomes.

Purpose of the Study:

  • To review the applications of avidin-biotin systems in targeted therapies.
  • To explore avidin-biotin technology for pretargeted drug delivery and vector targeting.

Main Methods:

  • Utilizing the high affinity between avidin (or streptavidin) and biotin.
  • Reviewing current literature on avidin-biotin systems for therapeutic applications.

Main Results:

  • Avidin-biotin systems allow separate administration of targeting antibodies and therapeutic molecules, reducing drug exposure in normal tissues.
  • Gene transfer of avidin into specific tissues enables localized concentration of therapeutic ligands.
  • The system facilitates transductional targeting of gene therapy vectors.

Conclusions:

  • Avidin-biotin technology is a versatile tool for pretargeting and drug delivery.
  • It enables targeted delivery of biotinylated compounds via avidin gene introduction.
  • The technology supports the targeting of viral vectors for therapeutic purposes.