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Effects of R51163 on intake and metabolism in moose
C C Schwartz1, K J Hundertmark, W R Lance
1Alaska Department of Fish and Game, Moose Research Center, Soldotna 99669.
Journal of Wildlife Diseases
|January 1, 1991
Summary
A novel sedative, R51163, reduced dry matter intake in bull moose for over a week. Effects were dose-dependent and allometric, with larger moose experiencing longer sedation.
Area of Science:
- Veterinary Pharmacology
- Wildlife Biology
- Animal Science
Background:
- R51163, a purine alkyl piperidine derivative, is a known sedative in cattle.
- Evaluating novel sedatives is crucial for wildlife management and research.
Purpose of the Study:
- To assess the efficacy and effects of R51163 in adult bull moose (Alces alces).
- To determine the impact of R51163 on feed intake and resting metabolism in moose.
Main Methods:
- Five adult bull moose were administered R51163 at a dose of 0.4 mg/kg body weight.
- Dry matter intake and resting metabolism were measured and compared to control groups.
- Allometric dose-response relationships were analyzed.
Main Results:
- Treated moose consumed significantly less dry matter for at least one week post-treatment (P < 0.05).
- No significant difference in median resting metabolism was observed on the day of injection.
- The coefficient of variation for resting metabolism was higher in treated individuals (15%) versus controls (8%).
- Sedative effects exhibited an allometric dose-response, with larger animals showing prolonged effects.
Conclusions:
- R51163 effectively reduces dry matter intake in bull moose.
- The sedative's effects are dose-dependent and influenced by animal size, suggesting allometric scaling.
- Further research is warranted to understand long-term metabolic impacts and optimal dosing for moose.