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Psychotic features associated with multiple sclerosis.

Mary H Kosmidis1, Maria Giannakou, Lambros Messinis

  • 1School of Psychology, Aristotle University of Thessaloniki, GR54124Thessaloniki, Greece. Kosmidis@psy.auth.gr

International Review of Psychiatry (Abingdon, England)
|March 18, 2010
PubMed
Summary
This summary is machine-generated.

Psychotic features can occur in multiple sclerosis (MS), though the link is unclear. Research suggests a connection possibly due to brain changes and requires further study for diagnosis and treatment.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Psychotic features, once thought rare, are increasingly reported in multiple sclerosis (MS).
  • The precise relationship and underlying causes between psychosis and MS remain incompletely understood.
  • Epidemiological and case studies suggest a correlation, noting co-occurrence, temporal links, and specific brain abnormalities.

Purpose of the Study:

  • To review current knowledge on psychosis occurrence in MS.
  • To examine potential etiological factors and their mechanisms.
  • To discuss diagnostic and treatment implications and suggest future research directions.

Main Methods:

  • Literature review of epidemiological, hospital-based, and case studies.
  • Analysis of data on co-occurrence, temporal relationships, and neuroimaging findings.
  • Synthesis of information on proposed etiological factors like demyelination and corticosteroid use.

Main Results:

  • Evidence suggests a higher-than-chance co-occurrence of psychosis and MS.
  • Periventricular white matter and temporal demyelination are associated brain abnormalities.
  • Regional demyelination and corticosteroid use are implicated but not fully explained etiologies.

Conclusions:

  • Further research into the pathophysiology of psychosis in MS is crucial.
  • Identifying at-risk patients and optimal pharmacological interventions requires deeper understanding.
  • Clarifying the central nervous system disease process can guide clinical practice.