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Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...

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Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
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Proliferative verrucous leukoplakia: a concise update.

J Bagan1, C Scully, Y Jimenez

  • 1Valencia University and Hospital General Universitario de Valencia, Valencia, Spain. bagan@uv.es

Oral Diseases
|March 18, 2010
PubMed
Summary
This summary is machine-generated.

Proliferative verrucous leukoplakia (PVL) is a persistent oral lesion, potentially linked to human papillomavirus (HPV), that transforms into squamous cell carcinoma. This condition is challenging to treat and frequently recurs.

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Area of Science:

  • Oral pathology
  • Oncology
  • Dermatology

Background:

  • Proliferative verrucous leukoplakia (PVL) is an oral mucosal condition with unclear causes.
  • It primarily affects older women, starting as slow-growing leukoplakia.
  • PVL can spread, become multifocal, and frequently involve the gingiva.

Purpose of the Study:

  • To investigate the characteristics and clinical behavior of Proliferative verrucous leukoplakia.
  • To understand the potential association with human papillomavirus (HPV).
  • To highlight the therapeutic challenges and recurrence rates associated with PVL.

Main Methods:

  • Clinical observation and case review of patients diagnosed with PVL.
  • Histopathological examination of lesions.
  • Potential investigation of HPV status in affected tissues (details not provided in abstract).

Main Results:

  • PVL presents as persistent leukoplakia that progresses over time.
  • Lesions develop exophytic, verrucous, or erythroplakic areas.
  • These areas show malignant transformation into squamous cell carcinomas.
  • PVL demonstrates resistance to treatment and a high rate of recurrence.

Conclusions:

  • Proliferative verrucous leukoplakia is a distinct clinicopathological entity.
  • It has a high potential for malignant transformation into oral squamous cell carcinoma.
  • PVL is notoriously difficult to manage therapeutically, with frequent recurrences observed.