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Related Experiment Video

Updated: Jun 15, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

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Published on: October 6, 2014

A Counselling Model for BRCA1/2 Genetic Susceptibility Testing.

Iris van Oostrom¹, Aad Tibben

¹Department of Clinical Genetics, Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands. i.vanoostrom@erasmusmc.nl.

Hereditary Cancer in Clinical Practice

|March 18, 2010

Summary

The extensive Huntington protocol for BRCA1/2 genetic testing counseling may not be necessary. A flexible, individualized BRCA1/2 counseling approach is proposed, focusing on patient needs and strengths.

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Area of Science:

Medical Genetics
Psychology
Clinical Counseling

Background:

The Huntington protocol, involving multiple sessions, was initially used for BRCA1/2 genetic susceptibility testing counseling.
Accumulating evidence on the psychological impact of BRCA1/2 testing necessitates a review of current counseling practices.

Purpose of the Study:

To review psychological studies on BRCA1/2 genetic susceptibility testing.
To evaluate the necessity of the extensive Huntington protocol for BRCA1/2 counseling.
To propose a revised, individualized BRCA1/2 counseling protocol.

Main Methods:

Literature review of psychological studies related to BRCA1/2 genetic testing.
Analysis of the "Huntington protocol" and its components.
Development of a flexible counseling protocol based on individual needs.

Main Results:

Evidence suggests the extensive Huntington protocol may not be universally required for BRCA1/2 genetic testing.
A flexible approach focusing on individual patient needs and strengths is supported by psychological research.

Conclusions:

The traditional "Huntington protocol" for BRCA1/2 genetic susceptibility testing counseling may be overly extensive.
A more individualized and flexible counseling approach is recommended for BRCA1/2 genetic testing, prioritizing patient-centered care.