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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
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Published on: November 11, 2022

Sodium hydroxymethylglycinate.

Kathryn Russell1, Sharon E Jacob

  • 1Department of Medicine, University of California, San Diego, School of Medicine, San Diego, CA, USA.

Dermatitis : Contact, Atopic, Occupational, Drug
|March 18, 2010
PubMed
Summary
This summary is machine-generated.

Sodium hydroxymethylglycinate (SHMG) is a formaldehyde-releasing preservative found in many products. Avoiding SHMG may improve symptoms for patients with formaldehyde allergies, suggesting a link to allergic contact dermatitis.

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Area of Science:

  • Dermatology
  • Toxicology
  • Cosmetic Science

Background:

  • Sodium hydroxymethylglycinate (SHMG) is a widely used preservative in consumer products like shampoos, soaps, and cleaning agents.
  • SHMG belongs to a class of chemicals known as formaldehyde-releasing preservatives.
  • Formaldehyde-releasing preservatives have been linked to allergic contact dermatitis.

Purpose of the Study:

  • To raise awareness among patients and healthcare providers about Sodium hydroxymethylglycinate (SHMG).
  • To highlight the potential role of SHMG in allergic contact dermatitis.

Main Methods:

  • Review of existing literature on Sodium hydroxymethylglycinate (SHMG) and formaldehyde-releasing preservatives.
  • Analysis of animal studies demonstrating sensitization and dermatitis potential of SHMG.
  • Examination of clinical reports of patients with formaldehyde allergy improving upon avoidance of SHMG-containing products.

Main Results:

  • Animal studies indicate that SHMG has the potential to cause sensitization and dermatitis.
  • Clinical observations suggest that patients allergic to formaldehyde may experience symptom improvement when avoiding products containing SHMG.
  • The allergic reactions could be due to SHMG itself, the formaldehyde it releases, or a combination of both.

Conclusions:

  • Sodium hydroxymethylglycinate (SHMG) is a significant preservative to consider in the context of allergic contact dermatitis.
  • Healthcare providers and patients should be aware of SHMG's presence in products and its potential as an allergen.
  • Further investigation may be warranted to fully elucidate the mechanisms of SHMG-induced hypersensitivity.