Related Experiment Video
Updated: Jun 15, 2026
07:39
Corneal and Limbal Alkali Injury Induction Using a Punch-Trephine Technique in a Mouse Model
Published on: August 4, 2023
Onset time course of solution induced corneal staining
Kalika L Bandamwar1, Qian Garrett, David Cheung
1The Institute for Eye Research, Sydney NSW, Australia. K.Bandamwar@brienholdenvision.org.au
Summary
Solution induced corneal staining in contact lens wearers increases over time, peaking at 60 minutes. This maximum staining level persists for at least two hours after lens insertion.
Area of Science:
- Ophthalmology
- Corneal Physiology
- Contact Lens Technology
Background:
- Solution-induced corneal staining (SICS) is a potential complication associated with contact lens wear.
- Understanding the time course of SICS is crucial for patient safety and lens care product development.
Purpose of the Study:
- To investigate the early phase time course of solution-induced corneal staining.
- To determine the onset and progression of corneal staining related to multipurpose contact lens solutions.
Main Methods:
- A prospective, double-masked, single-center clinical trial involving 25 participants (new and experienced contact lens wearers).
- Corneal staining was assessed using fluorescein and graded on the IER scale at 15, 30, 45, 60, and 120 minutes after wearing PureVision silicon hydrogel contact lenses with ReNu MultiPlus Multipurpose Solution.
- Measurements were randomized across separate days for each time point.
Main Results:
- Mean corneal staining was significantly greater in test eyes compared to control eyes at all measured time points post-insertion.
- Corneal staining extent in test eyes progressively increased up to 60 minutes post-insertion.
- Maximum staining severity and frequency were observed at 60 minutes, significantly higher than at earlier time points (15, 30, 45 minutes).
Conclusions:
- Solution-induced corneal staining develops gradually after contact lens insertion, reaching its peak at approximately 60 minutes.
- The maximum level of corneal staining observed at 1 hour was sustained for at least 2 hours post-insertion.
Related Concept Videos
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
01:14Time Course of Drug Effect
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50 percent of...