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Related Experiment Video

Updated: Jun 15, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Regional myocardial contractile function: multiparametric strain mapping.

Brian P Cupps1, Ajay K Taggar, Lina M Reynolds

  • 1Department of Surgery, Washington University School of Medicine, 660 South Euclid, Campus Box 8234, St. Louis, MO 63110, USA. cuppsb@wustl.edu

Interactive Cardiovascular and Thoracic Surgery
|March 18, 2010
PubMed
Summary
This summary is machine-generated.

Magnetic resonance imaging (MRI) with tissue tagging quantifies myocardial contractile function. This multiparametric strain analysis accurately identified regional differences in heart function after induced injury in sheep.

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Related Experiment Videos

Last Updated: Jun 15, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Published on: July 9, 2010

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Myocardial Pathophysiology

Background:

  • Magnetic resonance imaging (MRI) with tissue tagging allows for detailed assessment of myocardial strain.
  • Quantifying regional myocardial contractile function is crucial for understanding heart disease.
  • Developing robust methods to assess regional variations in cardiac function is an ongoing challenge.

Purpose of the Study:

  • To evaluate the efficacy of multiparametric strain analysis using MRI in quantifying regional myocardial contractile function.
  • To assess the ability of this technique to detect and delineate areas of myocardial injury in a pre-clinical model.
  • To establish the utility of normalized z-scores for characterizing regional cardiac performance.

Main Methods:

  • Induction of regional myocardial injury in an ovine model by ligating coronary artery blood supply.
  • Acquisition of left ventricular (LV) systolic strain data using tissue-tagged MRI.
  • Calculation of multiparametric systolic strain z-scores for 15,300 LV points using a normal strain database.
  • Statistical analysis to compare z-scores across different myocardial regions.

Main Results:

  • Multiparametric z-scores demonstrated significant regional variation (P<0.001) in myocardial contractile function.
  • Regions remote from the induced infarct showed significantly lower z-scores compared to infarcted areas.
  • The analysis successfully quantified and visually delineated regional functional differences.

Conclusions:

  • MRI-based multiparametric strain analysis is a valuable tool for assessing regional myocardial contractile function.
  • This technique accurately quantifies functional deficits in areas of myocardial injury.
  • The study provides pre-clinical validation for using this advanced imaging analysis in cardiovascular research.