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Related Experiment Video

Updated: Jun 15, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Periocular xanthogranuloma: A forgotten entity?

Charalampos Papagoras¹, George Kitsos, Paraskevi V Voulgari

¹Rheumatology Clinic, Department of Internal Medicine, University of Ioannina, Ioannina, Greece.

Clinical Ophthalmology (Auckland, N.Z.)

|March 18, 2010

Summary

Periocular xanthogranuloma, a rare condition causing eyelid swelling, can be associated with adult-onset asthma. Treatment with corticosteroids and cyclophosphamide showed significant improvement in a recent case study.

Keywords:

adult-onset asthma cyclophosphamide methylprednisolone non-Langerhans histiocytoses periocular xanthogranuloma

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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Last Updated: Jun 15, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Published on: August 9, 2024

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

Ophthalmology
Dermatology
Immunology

Background:

Periocular xanthogranulomatous diseases are rare, presenting diagnostic challenges.
Characterized by specific histopathological features like foamy histiocytes and Touton giant cells.

Observation:

A middle-aged man with a decade of eyelid swelling and new-onset atopic conditions (asthma, allergic rhinitis) was studied.
Clinical and histopathological examination, including eyelid biopsy, led to diagnosis of periocular xanthogranuloma associated with adult-onset asthma.

Findings:

Literature review revealed no prospective trials for this rare condition.
Corticosteroids and alkylating agents are suggested treatments based on case reports.

Implications:

The patient received combined oral corticosteroids and cyclophosphamide pulses.
This treatment led to significant regression of eyelid masses and normalized systemic immune abnormalities.