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Updated: Jun 15, 2026
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
Enzymatic degradation of supramolecular materials based on partial inclusion complex formation between
Haiya Luo1, Xianwei Meng, Cong Cheng
1State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan University, Chengdu 610065, People's Republic of China.
Abstract:
Supramolecular biomaterials were prepared based on the formation of partial inclusion complexes between alpha-CD and poly(epsilon-caprolactone) (PCL). Enzyme-catalyzed degradation of these partial alpha-CD-PCL inclusion complexes was investigated at 37 degrees C in the presence of lipase from pancreas porcine. The biodegradation behaviors were monitored by weight loss measurement, (1)H NMR, XRD, GPC, DSC, and SEM. It was found that the formation of inclusion segments significantly accelerated the degradation of materials. A mechanism of enzymatic degradation for partial alpha-CD-PCL inclusion complexes was proposed. The present study provides a preliminary understanding for the biodegradation of the materials constructed by self-assembly between cyclodextrin and polymers.
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