Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Stages of General Anesthesia

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...

Measurement of Blood Pressure

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.

Inhalational Anesthetics: Overview

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.

British journal of anaesthesia·2009

Same author

Differential electroencephalographic response to tracheal intubation between young and elderly during isoflurane and sevoflurane nitrous oxide anaesthesia.

British journal of anaesthesia·2007

Same author

Airway problems related to laryngeal mask airway use associated with an undiagnosed epiglottic cyst.

Anaesthesia and intensive care·2005

Same author

Relaxing intraoperative natural sound blunts haemodynamic change at the emergence from propofol general anaesthesia and increases the acceptability of anaesthesia to the patient.

Acta anaesthesiologica Scandinavica·2003

Same author

Induction and mechanism of apoptotic cell death by propofol in HL-60 cells.

Acta anaesthesiologica Scandinavica·2002

Same author

Echocardiographic diagnosis of extrapericardial tamponade due to dilated gastric roll following oesophagectomy.

Anaesthesia and intensive care·2002

Search research articles

Related Experiment Video

Updated: Jun 15, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Pleth variability index predicts hypotension during anesthesia induction.

M Tsuchiya¹, T Yamada, A Asada

¹Department of Anesthesiology, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, Osaka 545-8586, Japan. oxymasa@ea.mbn.or.jp

Acta Anaesthesiologica Scandinavica

|March 19, 2010

Summary

This summary is machine-generated.

Pre-anesthesia pleth variability index (PVI) effectively predicts significant blood pressure drops during anesthesia induction. This tool helps identify patients at high risk for hypotension, improving anesthetic management.

More Related Videos

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Published on: November 11, 2022

Related Experiment Videos

Last Updated: Jun 15, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Published on: November 11, 2022

Area of Science:

Anesthesiology
Critical Care Medicine
Cardiovascular Physiology

Background:

The pleth variability index (PVI) assesses respiratory variations in pulse oximetry amplitude.
PVI may predict fluid responsiveness and is explored for its role in anesthesia-induced hypotension.
Anesthesia-induced hypotension is linked to patient volume status.

Purpose of the Study:

To investigate if pre-anesthesia PVI can identify patients at high risk for significant blood pressure decrease during anesthesia induction.
To evaluate the predictive capability of PVI for hypotension following propofol administration.

Main Methods:

76 healthy adult patients undergoing light sedation had pre-anesthesia PVI, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) measured.
Anesthesia was induced with propofol and rocuronium.
Hemodynamic parameters were recorded at 30-second intervals during the 3 minutes post-propofol administration.

Main Results:

Propofol administration caused significant decreases in SBP (33%), DBP (23%), and MAP (26%).
Pre-anesthesia PVI showed a strong negative correlation with the decrease in MAP (r = -0.73).
A PVI >15 predicted a MAP decrease >25 mmHg with high sensitivity (0.79) and specificity (0.71).

Conclusions:

Pre-anesthesia PVI is a reliable predictor of mean arterial pressure decrease during propofol-induced anesthesia.
Measuring PVI before anesthesia can help identify patients susceptible to severe hypotension.
This finding supports the use of PVI for risk stratification in anesthesia.