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Related Experiment Video

Updated: Jun 15, 2026

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

Selectively targeting pain in the trigeminal system.

Hyun Yeong Kim¹, Kihwan Kim, Hai Ying Li

¹National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea Department of Physiology School of Medicine, Hanyang University, Seoul 133-791, Republic of Korea Department of Oral Physiology and Neurobiology School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea Department of Anatomy and Cell Biology College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan Neural Plasticity Research Group, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

|March 19, 2010

Summary

Researchers found that combining QX-314 with capsaicin selectively blocks pain signals in orofacial nerves. This targeted approach offers potential for treating dental and facial pain by inhibiting pain transmission without affecting motor function.

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Chronic Constriction Injury of the Distal Infraorbital Nerve (DIoN-CCI) in Mice to Study Trigeminal Neuropathic Pain

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Published on: July 26, 2022

Area of Science:

Neuroscience
Pharmacology
Pain Research

Background:

Pain signaling in the orofacial region relies on nociceptors.
Selective blockade of pain signals without affecting other functions is a therapeutic goal.

Purpose of the Study:

To investigate the selective blockade of orofacial pain signals using QX-314 delivered via TRPV1 channels.
To assess the effects of co-applied QX-314 and capsaicin on trigeminal system functions.

Main Methods:

Utilized rats to examine the effects of QX-314 and capsaicin on trigeminal ganglion neurons.
Measured voltage-gated sodium channel currents (I(Na)) and action potentials (APs).
Assessed the jaw-opening reflex and orofacial analgesia.

Main Results:

Co-application of QX-314 and capsaicin blocked I(Na) and APs in TRPV1-positive neurons but not TRPV1-negative neurons.
TRPV1 expression was absent in trigeminal motor and mesencephalic neurons.
The treatment inhibited the jaw-opening reflex and produced long-lasting orofacial analgesia.

Conclusions:

Selective pain signal blockade in the orofacial area is achievable by co-applying QX-314 with TRPV1 agonists.
This method demonstrates potential for treating dental and facial pain by targeting specific neuronal pathways.