Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Stanford Prison Experiment03:20

The Stanford Prison Experiment

The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
Repressed Memory01:16

Repressed Memory

Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
Milgram's Obedience to Authority02:20

Milgram's Obedience to Authority

Obedience to authority is classically demonstrated in a more famous series of social psychology experiments performed by Stanley Milgram. He was a social psychology professor at Yale who was influenced by the trial of Adolf Eichmann, a Nazi war criminal. Eichmann’s defense for the atrocities he committed was that he was “just following orders.”
False Memories01:18

False Memories

False memories represent a cognitive distortion in which individuals recall events that did not happen, or remember them in an altered form. This phenomenon highlights the brain's constructive nature in processing and recalling memories, emphasizing that memory is not a perfect representation of past events but rather a dynamic reconstruction influenced by various factors.
One primary source of false memories is misattribution, where individuals incorrectly associate external information with...
Torts III01:26

Torts III

Types of Quasi-intentional Torts in Healthcare
Quasi-intentional torts in healthcare involve acts where intent is not directed to harm an individual but results in harm due to careless or reckless speech.
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light bulb,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Profiling and Treatment Outcomes in Uterine Serous Carcinoma: Prognostic Role of Estrogen Receptor Expression.

Current oncology (Toronto, Ont.)·2026
Same author

Sacituzumab tirumotecan (sac-TMT/MK-2870/SKB264): a novel antibody-drug conjugate in breast cancer.

Oncology reviews·2026
Same author

The Hippo Pathway in Metaplastic Breast Carcinoma: Prognostic Significance and Therapeutic Implications.

Current issues in molecular biology·2026
Same author

Preoperative Breast MRI and Histopathology in Breast Cancer: Concordance, Challenges and Emerging Role of CEM and mpMRI.

Diagnostics (Basel, Switzerland)·2025
Same author

Podoplanin - Related Lymphatic Micro Vessel Density Digital Analysis in Breast Adenocarcinoma.

Cancer diagnosis & prognosis·2025
Same author

Correction: Prevention of spontaneous preterm birth.

Archives of gynecology and obstetrics·2025

Related Experiment Video

Updated: Jun 15, 2026

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
12:22

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

What have we really learned from 'LIBERATE' trial?

Constantine Dimitrakakis1, Alexandra Tsigginou, Dimitris Keramopoulos

  • 11st Department of Ob/Gyn, Athens University Medical School, Athens, Greece. atsigginou@med.uoa.gr

Maturitas
|March 19, 2010
PubMed
Summary

Tibolone may increase breast cancer recurrence risk in women with vasomotor symptoms, according to the LIBERATE trial. Further research is needed to identify patient subgroups who might safely use Tibolone.

More Related Videos

In Situ Gas Analysis and Fire Characterization of Lithium-Ion Cells During Thermal Runaway Using an Environmental Chamber
08:42

In Situ Gas Analysis and Fire Characterization of Lithium-Ion Cells During Thermal Runaway Using an Environmental Chamber

Published on: March 31, 2023

Related Experiment Videos

Last Updated: Jun 15, 2026

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
12:22

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

In Situ Gas Analysis and Fire Characterization of Lithium-Ion Cells During Thermal Runaway Using an Environmental Chamber
08:42

In Situ Gas Analysis and Fire Characterization of Lithium-Ion Cells During Thermal Runaway Using an Environmental Chamber

Published on: March 31, 2023

Area of Science:

  • Oncology
  • Hormone Therapy
  • Clinical Trials

Background:

  • Tibolone is a synthetic steroid hormone used for hormone replacement therapy.
  • Vasomotor symptoms are common in postmenopausal women, including breast cancer survivors.
  • The LIBERATE trial investigated Tibolone's efficacy and safety in breast cancer patients.

Purpose of the Study:

  • To evaluate the risk of breast cancer recurrence associated with Tibolone use.
  • To address uncertainties and limitations in the LIBERATE trial findings.
  • To determine if specific breast cancer patient subgroups can use Tibolone without increased relapse risk.

Main Methods:

  • Analysis of data from the LIBERATE clinical trial.
  • Assessment of breast cancer recurrence rates in patients using Tibolone.
  • Identification of potential patient subgroups based on clinical characteristics.

Main Results:

  • Tibolone use was associated with an increased risk of breast cancer recurrence.
  • The study identified limitations and uncertainties in the LIBERATE trial's interpretation.
  • Questions remain regarding the generalizability of findings to all breast cancer patients.

Conclusions:

  • Tibolone may pose a risk for breast cancer recurrence in patients with vasomotor symptoms.
  • Further investigation is required to clarify Tibolone's safety profile in specific breast cancer patient populations.
  • Personalized risk-benefit assessments are crucial for hormone therapy decisions in breast cancer survivors.