Related Experiment Video
Updated: Jun 15, 2026
12:28
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Right cerebral hemiatrophy: neurocognitive and electroclinical features
Asli Demirtas-Tatlidede1, A Destina Yalcin, Ender Uysal
1Department of Neurology, Sisli Etfal Research and Training Hospital, Istanbul, Turkey. aslidemirtas@yahoo.com
Epilepsy & Behavior : E&B
|March 19, 2010
Summary
Right cerebral hemiatrophy (Dyke-Davidoff-Masson syndrome) often causes intellectual disability and significant visuospatial impairments. Seizures are common, and EEG shows reduced activity in the affected right hemisphere.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Right cerebral hemiatrophy, also known as Dyke-Davidoff-Masson syndrome (DDMS), is a rare neurological condition.
- Understanding its cognitive and electroclinical profile is crucial for diagnosis and management.
Purpose of the Study:
- To retrospectively evaluate the cognitive and electroclinical characteristics of individuals with right-sided DDMS.
- To analyze neuroimaging findings in relation to cognitive and electroclinical features.
Main Methods:
- Retrospective analysis of five patients with confirmed right-sided DDMS.
- Cognitive assessments including intelligence tests and neuropsychological evaluations focusing on visuospatial functions.
- Analysis of electroclinical data (seizure types, EEG) and neuroimaging characteristics.
Main Results:
- All but one patient exhibited mental retardation.
- Consistent impairments were observed in visuospatial tasks (spatial processing, orientation discrimination).
- Seizure types included simple partial motor, complex partial, and secondarily generalized seizures; EEG showed reduced amplitude and slow activity in the affected hemisphere.
Conclusions:
- Cognitive deficits in DDMS are broad, affecting multiple domains.
- Findings support the hypothesis that dorsal visual pathways, crucial for spatial processing, may be right-hemisphere lateralized.
More Related Videos
Related Concept Videos
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:21Huntington Disease l: Introduction
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
01:05Cerebral Hemispheres
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...