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Nephrotic syndrome associated with invasive mole: a case report
Jae Won Yang1, Seung Ok Choi, Bi Ro Kim
1Department of Nephrology, Yonsei University Wonju College of Medicine, 162 Ilsan-dong, Wonju, Kangwon-do, South Korea.
Summary
Gestational trophoblastic neoplasia (GTN) can manifest with minimal change disease, a rare kidney complication. Successful treatment of the invasive mole led to complete remission of nephrotic syndrome in this case.
Area of Science:
- Gynecologic Oncology
- Nephrology
- Pathology
Background:
- Gestational trophoblastic disease encompasses various gynaecological tumours originating from the trophoblast.
- Invasive moles are the most common cause of localized gestational trophoblastic neoplasia (GTN).
- Previous reports linked GTN to membranous glomerulonephritis (MGN), but this association is not universal.
Observation:
- This case involved a patient with clinical features and pathological findings consistent with minimal change disease.
- Histological examination did not reveal evidence of membranous glomerulonephritis (MGN).
- The patient presented with nephrotic syndrome in conjunction with an invasive mole.
Findings:
- Minimal change disease was diagnosed in association with an invasive mole.
- Complete remission of nephrotic syndrome was achieved.
- Remission occurred following the surgical removal of the invasive mole.
Implications:
- This case highlights a potential, albeit rare, association between invasive moles and minimal change disease.
- It suggests that minimal change disease should be considered in patients with GTN and nephrotic syndrome, even without MGN.
- Nephrotic syndrome associated with invasive moles may be effectively treated by mole removal.
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