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Updated: Jun 15, 2026
10:21
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
G-CSF and its receptor in myeloid malignancy
1Department of Hematology, Erasmus MC, Rotterdam, The Netherlands.
Blood
|March 19, 2010
Summary
Granulocyte colony-stimulating factor (G-CSF) treats neutropenia and mobilizes stem cells but carries risks. Long-term use, especially in children, raises concerns about potential malignant transformation, particularly in those with G-CSF receptor mutations.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Granulocyte colony-stimulating factor (G-CSF) is a key therapeutic agent used for over 20 years.
- It treats neutropenias, mobilizes hematopoietic stem cells, and is explored in leukemia and aplastic anemia therapies.
Purpose of the Study:
- To review controversies and challenges in G-CSF clinical applications.
- To discuss the potential role of G-CSF in malignant transformation, especially in specific patient populations.
Main Methods:
- Literature review and discussion of existing clinical data.
- Focus on long-term G-CSF effects and specific genetic predispositions.
Main Results:
- G-CSF is effective for neutropenia and stem cell mobilization.
- Concerns exist regarding long-term safety, including increased risk of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
- This risk is particularly noted in children with severe congenital neutropenia on lifelong G-CSF and in patients with G-CSF receptor mutations.
Conclusions:
- While beneficial, G-CSF use requires careful consideration of potential adverse effects.
- Further long-term studies are crucial to fully understand and mitigate risks, especially concerning malignant transformation.
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