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Keratocystic odontogenic tumor
Elizabeth A Grasmuck1, Brenda L Nelson
1Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134-5000, USA. elizabeth.grasmuck@med.navy.mil
Head and Neck Pathology
|March 19, 2010
Summary
The keratocystic odontogenic tumor, a benign developmental lesion, presents unique clinical and histologic characteristics. Its potential for neoplastic transformation necessitates updated treatment strategies.
Area of Science:
- Oral pathology
- Developmental biology
- Oncology
Background:
- Keratocystic odontogenic tumor (KCOT) is a cystic lesion of the jaw.
- It exhibits distinct clinical and histological features.
- KCOT arises from the dental lamina.
Observation:
- This review examines the typical presentation of KCOT.
- Key clinical and histological characteristics are detailed.
- The neoplastic potential of KCOT is a significant consideration.
Findings:
- KCOT is a benign but locally aggressive odontogenic tumor.
- Histologically, it is characterized by a corrugated parakeratinized epithelial lining.
- Recurrence rates are notably high.
Implications:
- Understanding KCOT's features is crucial for accurate diagnosis.
- The acknowledged neoplastic potential impacts surgical management.
- Treatment strategies must address the risk of recurrence and malignant transformation.
