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Related Experiment Video

Updated: Jun 15, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Bile acids for liver-transplanted patients.

Goran Poropat1, Vanja Giljaca, Davor Stimac

  • 1Department of Gastroenterology, Clinical Hospital Centre Rijeka, Kresimirova 42, Rijeka, Croatia, 51000.

The Cochrane Database of Systematic Reviews
|March 19, 2010
PubMed
Summary

Bile acids show no significant impact on mortality or acute rejection in liver transplant recipients. While they may reduce chronic rejection, more research is needed to confirm their benefits and safety in these patients.

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Area of Science:

  • Hepatology
  • Transplantation Immunology
  • Gastroenterology

Background:

  • Liver transplantation is a key treatment for end-stage liver disease.
  • Bile acids may influence allograft rejection by altering MHC expression in liver tissues.

Purpose of the Study:

  • To evaluate the efficacy and safety of bile acids in liver transplant patients.
  • To assess the impact of bile acids on allograft rejection and patient survival.

Main Methods:

  • Systematic review and meta-analysis of randomized clinical trials.
  • Searched multiple databases including Cochrane, MEDLINE, and EMBASE up to September 2009.
  • Included trials comparing bile acids with placebo or no intervention in liver-transplanted patients.

Related Experiment Videos

Last Updated: Jun 15, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Main Results:

  • Seven trials with 335 participants were included, evaluating ursodeoxycholic acid and tauro-ursodeoxycholic acid.
  • Bile acids did not significantly affect all-cause mortality, rejection-related mortality, or retransplantation rates.
  • A potential reduction in chronic rejection was observed, but findings were inconsistent across meta-analysis models. Bile acids were generally well-tolerated.

Conclusions:

  • Current evidence is insufficient to support or refute the use of bile acids in liver transplant recipients.
  • Further high-quality randomized trials are required to establish the role of bile acids in post-liver transplantation care.