Angiogenesis-inhibitors for metastatic thyroid cancer

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Aihua Tan1, Ning Xia, Feng Gao

  • 1Center of Evidence Based Medicine, First Affiliated Hospital, Guangxi Medical University, Taoyuan Road, Nanning, Guangxi, China, 530001.

The Cochrane Database of Systematic Reviews
|March 19, 2010
PubMed
Abstract

Insights

No studies met inclusion criteria for evaluating angiogenesis-inhibitors in advanced thyroid cancer. More research is needed to determine the benefits and risks of these treatments.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Advanced thyroid carcinomas are challenging to treat with systemic cytostatic therapies.
  • Tumor growth and metastasis are critically dependent on angiogenesis.
  • Inhibiting angiogenesis presents a potential therapeutic strategy for thyroid cancer.

Purpose of the Study:

  • To assess the efficacy and safety of angiogenesis-inhibitors for metastatic thyroid cancer.
  • To evaluate their use as monotherapy or in combination with chemotherapy or radiotherapy.

Main Methods:

  • Comprehensive literature search of major databases (Cochrane, MEDLINE, EMBASE) and conference abstracts.
  • Inclusion criteria focused on randomized controlled trials in pathologically confirmed advanced thyroid cancer.
  • No studies met the full inclusion criteria, thus data extraction and bias assessment were not performed.

Main Results:

  • No randomized controlled trials were identified that met the study's inclusion criteria.
  • The search did not yield any eligible studies for meta-analysis or systematic review.

Conclusions:

  • There is currently a lack of high-quality evidence from randomized controlled trials on the benefits and harms of angiogenesis-inhibitors for advanced thyroid cancer.
  • Several clinical trials are ongoing, which may provide future evidence.

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