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Updated: Jun 15, 2026
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Published on: October 13, 2022
CaMPDB: a resource for calpain and modulatory proteolysis
David duVerle1, Ichigaku Takigawa, Yasuko Ono
1Bioinformatics Center, Kyoto University, Gokasho, Uji 611-0011, Japan. dave@kuicr.kyoto-u.ac.jp
Summary
Researchers created CaMPDB, a database for modulatory proteolysis, focusing on calpains. This resource organizes information on calpains, substrates, and inhibitors to aid understanding of cellular processes.
Area of Science:
- Biochemistry
- Molecular Biology
- Proteomics
Background:
- Modulatory proteolysis is crucial but poorly understood.
- Entities involved in this process, like calpains, have uncertain roles.
- Existing knowledge is disorganized, hindering research progress.
Purpose of the Study:
- To build CaMPDB, a centralized resource for modulatory proteolysis.
- To focus on calpains, a well-studied class of intracellular proteases.
- To provide tools and data for understanding calpain-mediated cellular functions.
Main Methods:
- Compiled sequences of calpains, substrates, and inhibitors from scientific literature.
- Included known substrate cleavage sites.
- Incorporated biochemical experimental data on cleavage efficiencies.
- Developed a cleavage site prediction tool.
Main Results:
- CaMPDB is a comprehensive database for calpain-related information.
- The database includes sequences, cleavage sites, and efficiency data.
- A predictive tool is available to analyze calpain activity.
Conclusions:
- CaMPDB organizes scattered information on modulatory proteolysis.
- The resource facilitates research into calpain functions.
- CaMPDB aids biologists in understanding calpain-mediated cellular processes.
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