Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimating human exposure through multiple pathways from air, water, and soil.

T E McKone1, J I Daniels

  • 1University of California, Lawrence Livermore National Laboratory, Livermore 94550.

Regulatory Toxicology and Pharmacology : RTP
|February 1, 1991
PubMed
Summary

This study introduces multipathway, multimedia models to estimate human exposure to environmental contaminants. These models use pathway exposure factors (PEFs) to link contaminant concentrations in air, water, and soil to chronic daily intake (CDI).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafine, fine, and black carbon particle concentrations in California child-care facilities.

Indoor air·2017
Same author

Model framework for integrating multiple exposure pathways to chemicals in household cleaning products.

Indoor air·2016
Same author

VOC exposures in California early childhood education environments.

Indoor air·2016
Same author

Formaldehyde and acetaldehyde exposure and risk characterization in California early childhood education environments.

Indoor air·2016
Same author

Indoor inhalation intake fractions of fine particulate matter: review of influencing factors.

Indoor air·2015
Same author

Estimated effect of ventilation and filtration on chronic health risks in U.S. offices, schools, and retail stores.

Indoor air·2015

Area of Science:

  • Environmental Science
  • Toxicology
  • Risk Assessment

Background:

  • Accurate estimation of human exposure to environmental contaminants is crucial for public health.
  • Existing models often lack the ability to integrate multiple exposure pathways and environmental media.

Purpose of the Study:

  • To develop and present a set of multipathway, multimedia models for estimating human exposure to environmental contaminants.
  • To introduce the concept and calculation of pathway exposure factors (PEFs) for quantifying exposure.
  • To demonstrate the application of these models using specific contaminants like arsenic, PCE, and TNT.

Main Methods:

  • Development of multipathway, multimedia models linking environmental contaminant concentrations to human exposure.
  • Incorporation of human physiology, lifestyle, and environmental partitioning into pathway exposure factors (PEFs).

Related Experiment Videos

  • Derivation of generalized PEFs for various exposure routes (inhalation, ingestion, dermal) across different media (air, water, soil).

    • Main Results:

    • Established models that translate contaminant concentrations in environmental media into chronic daily intake (CDI).
    • Derived generalized PEFs applicable to a wide range of environmental exposure scenarios.
    • Successfully applied the PEF expressions to estimate exposure for arsenic, tetrachloroethylene (PCE), and trinitrotoluene (TNT).

    Conclusions:

    • The developed models provide a robust framework for assessing human exposure to environmental contaminants.
    • Pathway exposure factors (PEFs) offer a standardized method for quantifying exposure across diverse pathways and media.
    • These models are valuable tools for environmental risk assessment and management.