[Medical treatment of epidermoid carcinoma of the anus]

From January 1987 to May 1988 11 patients with epidermoid carcinoma of the anus were treated with Chemotherapy and Radiotherapy, six female and five males, between 46 and 90 years and a medium of 66. Five patients had recurrent disease to a previous treatment of surgery, radiotherapy or both. Chemotherapy treatment consisted of Mitomicine C 15 mg/m2 on day 1 and 5--FU 1 g/m2/d IV by 96 hours infusion. In the last six patients Mitomycin C was changed to Cisplatin to a dose of 80-100 mg/m2 on day 1. Radiotherapy to the pelvis was started on the first day of QT, with the exception of two patients with disseminated disease. The total response rate was 90.8% (6 CR and 4 PR). Those patients that did not receive previous treatment, had a complete response in 83.3% of the cases. The three patients that received Cisplatin as initial treatment have a complete response. All patients that received the treatment with curative intention and had an initial complete response are without evidence of disease after 33 to 47 months of follow up.