Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute, persistent quinine-induced blindness. A case report.

P Rheeder1, W L Sieling

  • 1Department of Medicine, 1 Military Hospital, Voortrekkerhoogt, Tvl.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|May 4, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimising insulin use in people living with type 2 diabetes at primary healthcare facilities: The Tshwane Insulin Project.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

The association between serum fructosamine and random spot urine fructose levels with the severity of non-alcoholic fatty liver disease - an analytical cross-sectional study.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Recurrent venous thrombosis - an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in tshwane, south africa.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2021
Same author

Identification of a subgroup of black South Africans with type 1 diabetes who are older at diagnosis but have lower levels of glutamic acid decarboxylase and islet antigen 2 autoantibodies.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Titrating insulin in patients with type 2 diabetes using a structured self-monitoring blood glucose regimen.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2018
Same journal

SAMA Health Summit Abstracts.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
See all related articles

Quinine, an essential malaria treatment, can cause total and permanent blindness, a rare and severe side effect. Physicians must be aware of this risk, even though visual deficits usually resolve quickly.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Infectious Diseases

Background:

  • Quinine is a critical medication for malaria treatment.
  • Adverse effects of quinine can occur, including visual disturbances.
  • Previous reports suggest quinine-induced visual deficits are typically transient and mild.

Observation:

  • A case of a young man treated empirically for malaria is presented.
  • The patient developed total and permanent blindness following quinine administration.
  • This outcome is unusual compared to previously documented cases.

Findings:

  • The reported case demonstrates a rare, severe manifestation of quinine toxicity.
  • Permanent vision loss is a significant deviation from the usual prognosis of quinine-induced visual impairment.

Related Experiment Videos

  • The patient's blindness did not resolve over time.

    • Implications:

    • Clinicians must maintain a high index of suspicion for severe quinine toxicity.
    • Awareness of potential permanent visual deficits is crucial for patient counseling and monitoring.
    • This case highlights the importance of risk-benefit assessment in empirical malaria treatment.