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Related Experiment Videos

Factor VII hyperactivity in the elderly.

K Kario1, T Matsuo, K Nakao

  • 1Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Japan.

Thrombosis and Haemostasis
|January 23, 1991
PubMed
Summary

Coagulation factor VII (FVII) levels increase with age, particularly in elderly women and those with atherosclerosis. This suggests accelerated hepatic FVII synthesis and activation in older individuals, especially those with cardiovascular disease.

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Area of Science:

  • Gerontology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Aging is associated with changes in hemostasis.
  • Coagulation factor VII (FVII) plays a key role in the extrinsic pathway of coagulation.
  • Understanding age-related alterations in FVII is crucial for assessing thrombotic risk in the elderly.

Purpose of the Study:

  • To investigate the age-related increase in coagulation factor VII (FVII) activity and antigen levels.
  • To determine the significance of these changes in elderly individuals, particularly in relation to atherosclerosis.
  • To explore the correlation of FVII levels with hepatic protein synthesis and lipid profiles.

Main Methods:

  • Measured FVII coagulation activity (FVIIc), FVII antigen (FVIIag), and D-dimer in 150 subjects aged 60-98 years.

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  • Assessed blood lipid fractions and serum cholinesterase activity (ChE) as indicators of hepatic function.
  • Compared FVII levels between elderly and younger controls, and between elderly men and women, as well as atherosclerotic and non-atherosclerotic groups.

    • Main Results:

    • Elderly subjects exhibited significantly higher FVIIc, FVIIag, and D-dimer levels compared to younger controls.
    • FVIIc and FVIIag levels were significantly higher in elderly women than in elderly men.
    • Both FVIIc and FVIIag were elevated in subjects with atherosclerosis, with higher FVIIc/FVIIag ratios and ChE levels observed in this group.

    Conclusions:

    • Age-related increases in FVII synthesis and activation are evident in the elderly population.
    • Atherosclerosis is associated with further elevations in FVII levels and activity, suggesting a prothrombotic state.
    • Hepatic FVII synthesis, indicated by ChE correlation, appears to be accelerated in elderly individuals, particularly those with atherosclerosis.