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Multilocular cystic renal cell carcinoma.
1Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611.
American Journal of Clinical Pathology
|May 1, 1991
Summary
Multilocular cystic renal cell carcinoma (MCRCC) is a distinct kidney cancer subtype. This study found MCRCC to be a low-grade variant with no recurrence or metastasis in six cases over a ten-year period.
Area of Science:
- Urologic Oncology
- Nephrology
- Pathology
Background:
- Multilocular cystic renal cell carcinoma (MCRCC) is recognized as a distinct subtype of renal cell carcinoma.
- Understanding its behavior and characteristics is crucial for patient management and treatment strategies.
Purpose of the Study:
- To characterize the clinicopathological features of MCRCC.
- To evaluate the long-term outcomes of patients diagnosed with MCRCC.
Main Methods:
- Retrospective analysis of six MCRCC cases diagnosed between 1977 and 1987.
- Histopathological examination including nuclear grade and mitotic activity assessment.
- Flow-cytometric analysis of paraffin-embedded tumor tissue for ploidy and proliferative activity.
Main Results:
- MCRCC presented as well-demarcated, multicystic lesions with neoplastic clear cells (grade 1, low mitotic activity).
- Cyst walls were fibrotic, often lacking epithelial lining.
- Flow cytometry revealed diploid tumors with low proliferative activity in all tested cases.
- No recurrence or metastasis was observed in six MCRCC cases followed for at least two years.
Conclusions:
- MCRCC appears to be a low-grade variant of renal cell carcinoma.
- Further research is warranted to establish optimal therapeutic approaches for MCRCC.