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Massive acute arsenic poisoning.

D M Jolliffe1, A J Budd, D J Gwilt

  • 1Department of Anaesthetics and Intensive Care, Milton Keynes General Hospital, Eaglestone, Buckinghamshire.

Anaesthesia
|April 1, 1991
PubMed
Summary

A 28-year-old male died by suicide after ingesting 75g of arsenic trioxide. This case report details the clinical presentation, management, and autopsy findings of acute arsenic poisoning.

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Area of Science:

  • Toxicology
  • Forensic Pathology
  • Clinical Medicine

Background:

  • Arsenic trioxide is a highly toxic compound with a history of use in homicides and suicides.
  • Intentional ingestion of large quantities of arsenic trioxide presents a significant clinical challenge.

Observation:

  • A 28-year-old male presented following a deliberate ingestion of 75 grams of arsenic trioxide.
  • The patient's clinical course was rapidly fatal, necessitating intensive medical intervention.

Findings:

  • Postmortem examination revealed characteristic findings consistent with acute arsenic toxicity.
  • Histopathological analysis confirmed widespread tissue damage attributable to arsenic poisoning.

Implications:

  • This case underscores the lethal potential of arsenic trioxide and the importance of prompt recognition and management of poisoning.
  • Understanding the presentation and autopsy findings is crucial for forensic investigations and public health awareness regarding toxic substance abuse.

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