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Pain and measles, mumps, and rubella vaccination
1Eastern Health Board, Community Care Area 7, Aras Daimhin, Dublin, Republic of Ireland.
Archives of Disease in Childhood
|March 1, 1991
Insights
Pain from the measles, mumps, and rubella (MMR) vaccine was assessed in infants. MMR II vaccine caused significantly more crying, indicating greater injection pain, compared to Pluserix.
Area of Science:
- Pediatric medicine
- Vaccinology
- Immunology
Background:
- The measles, mumps, and rubella (MMR) vaccine is a routine childhood immunization.
- Assessing vaccine-associated pain is crucial for infant comfort and adherence to vaccination schedules.
Purpose of the Study:
- To compare the injection pain caused by two commonly used measles, mumps, and rubella (MMR) vaccines: Pluserix and MMR II.
Main Methods:
- A randomized, double-blind study involving 77 children (mean age 44.2 months).
- Pain was objectively measured by the amount of infant crying post-injection.
Main Results:
- Infants receiving the MMR II vaccine exhibited 2.31 times more crying compared to those who received the Pluserix vaccine.
- This suggests a statistically significant difference in perceived injection pain between the two MMR vaccines.
Conclusions:
- The MMR II vaccine is associated with a higher likelihood of injection pain in children compared to the Pluserix vaccine.
- These findings can inform healthcare providers and parents when selecting an MMR vaccine formulation to minimize infant discomfort.
Abstract:
Seventy-seven children (mean age 44.2 months) were entered in a randomised double blind study to find out if two commonly used measles, mumps, and rubella (MMR) vaccines (Pluserix and MMR II) caused pain on injection. Pain was judged by the amount of crying. Infants given MMR II were 2.31 times more likely to cry than those given Pluserix.