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Potent HIV-1 protease inhibitors with antiviral activities in vitro
H L Sham1, D A Betebenner, N E Wideburg
1Abbott Laboratories, Pharmaceutical Discovery Division, Illinois 60064-3500.
Biochemical and Biophysical Research Communications
|March 29, 1991
Abstract:
A series of novel difluoroketones with low molecular weight (less than 600 m.u.) and which are potent inhibitors of the HIV-1 protease (IC50 = 1.0 to 21 nM) were synthesized. These compounds also exhibited antiviral activity by inhibition of the cytopathic effect of HIV-1(3)B in MT-4 cells in vitro.