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Related Experiment Videos

Renal transplantation without steroids.

J R Salaman1

  • 1Department of Surgery and Transplantation, Royal Infirmary, Cardiff, Wales, UK.

Pediatric Nephrology (Berlin, Germany)
|January 1, 1991
PubMed
Summary

Cyclosporin monotherapy is effective for most kidney transplant patients, achieving an 80% 1-year graft survival rate. Adding steroids or azathioprine did not improve outcomes but increased infection risk, making cyclosporin monotherapy the preferred choice.

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Enalapril and cyclosporin in renal transplant patients and rats.

Transplantation proceedings·1994

Area of Science:

  • Nephrology
  • Immunosuppression
  • Transplantation

Background:

  • Cyclosporin has been a cornerstone in renal transplant recipient treatment since 1982.
  • Assessing the efficacy of cyclosporin-based immunosuppressive regimens is crucial for optimizing graft survival and patient outcomes.

Purpose of the Study:

  • To compare cyclosporin monotherapy with combination therapies (cyclosporin with steroids, cyclosporin with azathioprine) in renal transplant recipients.
  • To evaluate the impact of different immunosuppressive strategies on graft survival and infection rates.

Main Methods:

  • Two controlled clinical trials were conducted.
  • Cyclosporin monotherapy was compared against cyclosporin plus steroids and cyclosporin plus azathioprine.

Main Results:

  • The addition of steroids to cyclosporin did not enhance graft survival but increased infection incidence.
  • Adding azathioprine to cyclosporin also showed no benefit for graft outcome.
  • Cyclosporin monotherapy demonstrated an 80% 1-year survival rate for cadaveric kidney transplants.

Conclusions:

  • Cyclosporin monotherapy provides adequate immunosuppression for the majority of unsensitised renal transplant patients.
  • While triple therapy offers stronger immunosuppression for specific cases (sensitised patients, children), its graft survival rates are comparable to monotherapy in this study.
  • The study advocates for cyclosporin monotherapy as the primary treatment for unsensitised renal transplant recipients due to its efficacy and favorable side-effect profile.

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