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Related Experiment Videos

Histiocytes in Sweet's syndrome.

J Delabie1, C De Wolf-Peeters, M Mooren

  • 1Department of Pathology, University Hospital, Leuven, Belgium.

The British Journal of Dermatology
|April 1, 1991
PubMed
Summary

Sweet's syndrome biopsies reveal histiocytes mimicking neutrophils. Cytokines from these cells may drive the condition's characteristic skin lesions and systemic symptoms.

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Area of Science:

  • Dermatopathology
  • Immunology
  • Hematology

Background:

  • Sweet's syndrome is an acute febrile neutrophilic dermatosis.
  • Its pathogenesis, particularly the role of infiltrating cells, remains incompletely understood.

Purpose of the Study:

  • To investigate the cellular infiltrate in Sweet's syndrome biopsies.
  • To elucidate the potential role of specific cytokines in disease initiation.

Main Methods:

  • Histological examination of 18 Sweet's syndrome biopsy specimens.
  • Immunophenotyping of dermal infiltrate cells.

Main Results:

  • The majority of cases showed dermal infiltrates predominantly composed of histiocytes, not neutrophils.
  • Immunophenotyping identified these histiocytes as monocyte-derived.
  • Only leukemia-associated cases exhibited neutrophilic infiltration.

Conclusions:

  • Histiocytes, rather than neutrophils, are the primary infiltrate in most Sweet's syndrome cases.
  • Monocyte/histiocyte-derived cytokines (e.g., IL-1, IL-8) are implicated in the pathogenesis of Sweet's syndrome.
  • These cytokines may be responsible for systemic manifestations and neutrophil recruitment in skin lesions.

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