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Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states
I B Bezprozvanny1, D S Benevolensky, A P Naumov
1Academy of Sciences of the USSR, Institute of Cytology, Leningrad.
Abstract:
The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS (400/100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7 Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.
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