Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isotretinoin and lung function in systemic sclerosis.

C B Bunker1, P D Maurice, S Little

  • 1Department of Dermatology, University College and Middlesex School of Medicine, Middlesex Hospital, London, UK.

Clinical and Experimental Dermatology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary incontinence and female genital lichen sclerosus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Preventing penile cancer and poor outcomes.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Reply to 'EuroGuiderm Guideline on lichen sclerosus-introduction into lichen sclerosus'.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Letter to editor regarding: "Treatment algorithm for the comprehensive management of severe lichen sclerosus in boys based on the pathophysiology of the disease".

Journal of pediatric urology·2025
Same author

Reply to 'EuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus'.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

A case of COVID-19-related vulval ulceration coupled with genital viral shedding.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023

Synthetic retinoid isotretinoin may negatively impact lung function in systemic sclerosis patients. Further studies are needed to confirm these findings and assess risks for other conditions.

Area of Science:

  • Pulmonology
  • Dermatology
  • Rheumatology

Background:

  • Systemic sclerosis is a complex autoimmune disease affecting connective tissues.
  • Isotretinoin, a synthetic retinoid, is used to treat various dermatological conditions.
  • Potential adverse effects of isotretinoin on pulmonary function require investigation.

Purpose of the Study:

  • To evaluate the impact of isotretinoin on pulmonary function in patients with systemic sclerosis.
  • To compare lung function changes in isotretinoin-treated patients versus a control group.

Main Methods:

  • An open prospective study involving ten systemic sclerosis patients treated with isotretinoin.
  • Retrospective comparison of pulmonary function tests (PFTs) between treated patients and a matched control group.

Related Experiment Videos

  • Monitoring for adverse events such as pleural effusion and changes in PFTs.

    • Main Results:

    • One patient developed eosinophilic pleural effusion.
    • Two patients showed asymptomatic deterioration in pulmonary function tests.
    • Isotretinoin-treated patients exhibited a significantly greater decrease in 1-second forced expiratory volume (FEV1) and transfer coefficient compared to controls.

    Conclusions:

    • Isotretinoin treatment may be associated with adverse effects on lung function in systemic sclerosis patients.
    • Further research is warranted to investigate lung function changes in patients treated with isotretinoin for other indications.
    • Caution is advised when considering isotretinoin for systemic sclerosis patients with pre-existing pulmonary concerns.