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Pyoderma gangrenosum and malignant pyoderma in Nigeria.

O E Obasi1

  • 1Department of Medicine, Ahmadu Bello University Teaching Hospital, Kaduna, Nigeria.

Clinical and Experimental Dermatology
|January 1, 1991
PubMed
Summary

This study reports on five Nigerian patients with pyoderma gangrenosum (PG). Treatment with antibiotics, dapsone, and rifampicin showed varied success, with one patient progressing to malignant pyoderma gangrenosum.

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Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • Limited data exists on PG management in African populations.

Observation:

  • Five patients (four Nigerian males, one Polynesian female) diagnosed with PG between 1974-1984.
  • Lesion presentation varied from localized to extensive ulcerative forms.
  • Mean age was 25.6 years, ranging from 12 to 42 years.

Findings:

  • Standard wound care with antibiotics achieved healing in two patients.
  • Combination therapy with dapsone and rifampicin resulted in complete healing for two patients.
  • One patient experienced only transient remission and later died from malignant pyoderma gangrenosum.

Implications:

  • Highlights the challenges in treating severe pyoderma gangrenosum.
  • Suggests potential therapeutic roles for dapsone and rifampicin in refractory cases.
  • Underscores the risk of disease progression to a fatal malignant form.

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