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Related Experiment Videos

Perfluorocarbon-associated gas exchange.

B P Fuhrman1, P R Paczan, M DeFrancisis

  • 1Department of Anesthesiology/Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, PA 15213.

Critical Care Medicine
|May 1, 1991
PubMed
Summary

Perfluorocarbon-associated gas exchange (PAGE) offers a novel method for gas exchange, utilizing conventional ventilators. This technique was well-tolerated in piglets and showed efficiency comparable to positive-pressure breathing.

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Area of Science:

  • Pulmonary medicine
  • Biomedical engineering
  • Respiratory physiology

Background:

  • Liquid ventilation using perfluorocarbon improves gas exchange in lung conditions.
  • Conventional liquid ventilation requires specialized investigational devices.
  • A new method, perfluorocarbon-associated gas exchange (PAGE), integrates liquid ventilation principles with standard mechanical ventilation.

Purpose of the Study:

  • To evaluate the feasibility and efficacy of perfluorocarbon-associated gas exchange (PAGE) in a preclinical model.
  • To compare the gas exchange efficiency and physiological tolerance of PAGE with conventional positive-pressure breathing.

Main Methods:

  • Perfluorocarbon liquid was instilled into the lungs of 13 normal piglets (30 mL/kg).
  • Standard volume-regulated mechanical ventilation with 100% oxygen was resumed.

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  • Perfluorocarbon was continuously bubble-oxygenated within the lungs for 1 hour, participating directly in gas exchange.

    • Main Results:

    • Arterial oxygen (PaO2) and carbon dioxide (PaCO2) levels were maintained within normal ranges.
    • Peak airway pressures during PAGE were similar to those during conventional positive-pressure breathing.
    • Venous oxygen saturation and blood pH remained normal throughout the procedure.

    Conclusions:

    • Perfluorocarbon-associated gas exchange (PAGE) is a well-tolerated and effective gas exchange method.
    • The efficiency of PAGE approaches that of conventional positive-pressure breathing.
    • PAGE technology may overcome limitations of current instrumentation for treating lung diseases.