Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diastolic function in coronary artery disease.

J D Carroll1, E P Carroll

  • 1Department of Medicine, University of Chicago.

Herz
|February 1, 1991
PubMed
Summary

Diastolic dysfunction in coronary artery disease involves impaired left ventricular filling due to acute ischemia or myocardial infarction. Key factors include altered relaxation and increased stiffness, impacting cardiac function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitral transcatheter edge-to-edge repair: guidance in dogs from the human experience.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2025
Same author

Digital image correlation and infrared thermography data for seven unique geometries of 304L stainless steel.

Scientific data·2024
Same author

First pass cable artefact correction for cardiac C-arm CT imaging.

Physics in medicine and biology·2014
Same author

Multidimensional scaling.

Annual review of psychology·2010
Same author

Trehalose synthase converts glycogen to trehalose.

The FEBS journal·2008
Same author

Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT.

The European respiratory journal·2004

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Coronary artery disease (CAD) significantly impacts cardiac function, particularly diastolic function.
  • Diastolic abnormalities manifest distinctly during acute ischemia and after myocardial infarction (MI).

Purpose of the Study:

  • To review the pathophysiology of diastolic abnormalities in acute ischemia and post-myocardial infarction syndromes.
  • To elucidate the mechanisms underlying altered left ventricular filling in CAD.

Main Methods:

  • Review of existing clinical and experimental studies on diastolic function in CAD.
  • Analysis of factors influencing the diastolic pressure-volume relation.

Main Results:

  • Acute ischemia increases left ventricular filling pressures, potentially causing pulmonary edema.
  • Silent ischemia results in a lesser increase in filling pressures compared to symptomatic ischemia.
  • Post-MI, myocardial fibrosis elevates filling pressures, influenced by volume status.
  • Diastolic dysfunction involves impaired myocardial relaxation and increased muscle stiffness, shifting the pressure-volume relation upwards.

Conclusions:

  • Impaired myocardial relaxation is central to diastolic dysfunction during acute ischemia.
  • Increased extracellular matrix, particularly collagen, leads to permanent muscle stiffness and chronic diastolic abnormalities in CAD.

Related Experiment Videos