Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute amiodarone-induced hepatitis.

N Kalantzis1, P Gabriel, J Mouzas

  • 1Department of Gastroenterology and Histology, NIMTS Hospital, Athens, Greece.

Hepato-Gastroenterology
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).

European journal of obstetrics, gynecology, and reproductive biology·2023
Same author

The challenge of comparing digitally captured signatures registered with different software and hardware.

Forensic science international·2021
Same author

Features of digitally captured signatures vs. pen and paper signatures: Similar or completely different?

Forensic science international·2020
Same author

[Training in fetal ultrasound biometry: Prospective assesment of Objective Structured Assessment of Ultrasound Skills (OSAUS) efficiency].

Gynecologie, obstetrique, fertilite & senologie·2020
Same author

Treatment data and technical process challenges for practical big data efforts in radiation oncology.

Medical physics·2018
Same author

Anesthetic Considerations for an Adult Patient with Freeman-Sheldon Syndrome Undergoing Open Heart Surgery.

Case reports in anesthesiology·2018

High loading doses of amiodarone can cause acute, fatal liver injury. This study suggests re-evaluating amiodarone administration methods and dosages to prevent severe drug-induced hepatitis.

Area of Science:

  • Hepatology
  • Pharmacology
  • Toxicology

Background:

  • Amiodarone is an effective antiarrhythmic drug.
  • High loading doses are often used for rapid therapeutic effect.

Observation:

  • Two patients developed acute, confluent, necrotic hepatitis after high-dose amiodarone.
  • Symptoms included jaundice, hepatomegaly, elevated transaminases, and coagulopathy.

Findings:

  • Liver biopsies showed acute drug-induced hepatitis with extensive necrosis.
  • Fatal outcomes occurred due to hepatic coma and acute renal failure.

Implications:

  • Rapid administration of high-dose amiodarone may lead to severe hepatotoxicity.
  • Reconsideration of amiodarone's dosage and administration is crucial.

Related Experiment Videos