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Related Experiment Videos

Multisite microprobes for neural recordings.

N A Blum1, B G Carkhuff, H K Charles

  • 1Applied Physics Laboratory, Johns Hopkins University, Laurel, MD 20723.

IEEE Transactions on Bio-Medical Engineering
|January 1, 1991
PubMed
Summary
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New multisite microprobes enable simultaneous recording of neural activity from multiple brain locations. These passive probes, fabricated using integrated circuit techniques, show promising longevity in physiological environments.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Simultaneous recording of neural activity is crucial for understanding complex brain functions.
  • Existing technologies may have limitations in spatial resolution or longevity.
  • Development of advanced neural recording tools is an ongoing area of research.

Purpose of the Study:

  • To develop and characterize novel multisite, passive microprobes for simultaneous neural recording.
  • To evaluate the fabrication process and performance of these microprobes.
  • To demonstrate the utility of the microprobes in acute neurophysiological experiments.

Main Methods:

  • Microprobes fabricated using standard integrated circuit techniques with gold electrodes and polyimide dielectric layers.

Related Experiment Videos

  • Planar, dagger-shaped probe design with 4 or 6 recording sites (approx. 25 microns sq).
  • Encapsulation of probe head with silicone RTV and epoxy for protection; impedance and lifetime testing in saline.

    • Main Results:

    • Microprobes successfully fabricated with 4 or 6 recording sites.
    • Site impedances at 1 kHz typically between 2-4 M omega.
    • Probe lifetimes exceeded 750 hours in continuous saline immersion.
    • Action potential activity recorded from dorsal column nuclei neurons in anesthetized rats.

    Conclusions:

    • Multisite, passive microprobes offer a viable method for simultaneous multi-neuron recordings.
    • The fabrication process is compatible with standard integrated circuit techniques.
    • The probes demonstrate sufficient performance and longevity for acute neurophysiological studies.