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Stimulation of Ig production and growth of human lymphoblastoid B-cell lines by nerve growth factor

H Kimata1, A Yoshida, C Ishioka

  • 1Department of Pediatrics, Faculty of Medicine, Kyoto University Hospital, Japan.

Immunology
|March 1, 1991
PubMed

The effects of nerve growth factor (NGF) on human lymphoblastoid B-cell lines were studied. NGF increased Ig production and proliferation by lymphoblastoid B-cell lines GM-1500, GM-1056 and CBL in a dose-dependent manner. As little as 0.01 ng/ml of NGF was effective. This effect was blocked by anti-NGF serum but not by control serum. Other cytokines, including interleukin (IL)-1 beta, IL-2, IL-4, IL-5, interferon (IFN)-alpha, IFN-beta, IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF), did not stimulate Ig production. These results indicate that, in addition to its neurotropic effect NGF also acts as B-cell stimulatory factor.

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