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Antihypertensive effect of tiapamil from ambulatory and clinic methods

D G Blanchett1, C N Corder, P Kezdi

  • 1St. Anthony Hospital Foundation, Oklahoma City, OK.

International Journal of Clinical Pharmacology, Therapy, and Toxicology
|February 1, 1991
PubMed

Insights

Tiapamil effectively lowered blood pressure in hypertensive patients. However, responses measured by automatic blood pressure monitoring did not predict clinic blood pressure readings, indicating variability in measurement methods.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension management requires effective antihypertensive agents.
  • Calcium antagonists are a class of drugs used to treat hypertension.
  • Tiapamil is a calcium antagonist with potential antihypertensive properties.

Purpose of the Study:

  • To evaluate the efficacy of Tiapamil in reducing blood pressure in hypertensive patients.
  • To compare blood pressure readings obtained from automatic blood pressure monitoring (AMBP) and cuff and stethoscope clinic blood pressure (CBP) measurements.
  • To assess the correlation between blood pressure responses measured by AMBP and CBP.

Main Methods:

  • A double-blind, placebo-controlled study involving 58 hypertensive patients.
  • Patients received placebo, Level I Tiapamil (150-300 mg/day), or Level II Tiapamil (450-600 mg/day) for six weeks.
  • Blood pressure (systolic and diastolic) and heart rate were measured using both 24-h AMBP and CBP.

Main Results:

  • Tiapamil at Level II significantly reduced SBP and DBP as measured by AMBP.
  • Both Level I and Level II Tiapamil significantly reduced SBP and DBP as measured by CBP.
  • A minimal correlation (r = 0.16) was observed between blood pressure changes measured by AMBP and CBP.
  • No significant effect of Tiapamil on heart rate was observed.
  • Dizziness was reported in 12% of patients receiving Tiapamil.

Conclusions:

  • Tiapamil effectively lowers systolic and diastolic blood pressure in hypertensive patients.
  • Blood pressure responses to Tiapamil measured by AMBP do not reliably predict responses measured by CBP.
  • Further research may be needed to understand the discrepancy between AMBP and CBP measurements in response to Tiapamil.

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