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Helvecardins A and B, novel glycopeptide antibiotics. III. Biological properties
M Takeuchi1, T Katayama, M Inukai
1Fermentation Research laboratories, Sankyo Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|March 1, 1991
Abstract:
Helvecardins (HVCs) A and B were strongly active against aerobic and anaerobic Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), but they were inactive against Gram-negative bacteria and fungi. Though HVC A showed only slightly stronger antimicrobial activity than beta-avoparcin (AVP), its in vivo protective activity against S. aureus infection in mice was greatly superior to AVP.