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Related Experiment Videos

Biocompatible implantable antimicrobial release for necrotizing external otitis.

E J Ostfeld1, A Kupferberg

  • 1Department of Otolaryngology, Hillel Yaffe Medical Center, Hadera, Israel.

The Journal of Laryngology and Otology
|April 1, 1991
PubMed
Summary

A novel implantable antimicrobial release system (IARS) effectively treated necrotizing external otitis (NEO), eradicating infection and reducing hospital stays. This system offers a promising alternative to systemic antibiotics for difficult-to-treat cases.

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Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Necrotizing external otitis (NEO) is a severe infection often requiring prolonged antibiotic treatment.
  • Systemic antibiotic administration for NEO can lead to resistance or contraindications.
  • Alternative therapeutic strategies are needed for effective NEO management.

Purpose of the Study:

  • To evaluate the efficacy of a surgically implantable, antimicrobial release system (IARS) as the sole treatment for necrotizing external otitis.
  • To assess the safety and clinical outcomes of using gentamicin-incorporated polymethyl-methacrylate beads in NEO patients.

Main Methods:

  • Six patients with necrotizing external otitis received surgically implanted gentamicin-incorporated polymethyl-methacrylate beads.

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  • The beads were surgically removed after two months.
  • Clinical symptoms, infection eradication, hospitalization duration, and complications were monitored.

    • Main Results:

    • Complete eradication of Pseudomonas infection was achieved in 100% of patients.
    • Significant alleviation of clinical symptoms including pain, swelling, and otorrhoea was observed.
    • Hospitalization duration was substantially shortened (4-15 days).

    Conclusions:

    • The implantable antimicrobial release system (IARS) is an effective alternative to systemic antibiotics for eradicating NEO.
    • IARS demonstrated significant clinical improvement and infection control in NEO patients.
    • Potential complications include hearing loss and meatal stenosis, requiring careful monitoring.