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Related Experiment Videos

Polymorphonuclear and monocyte functions in measles.

U M Thatte1, P S Gangal, M R Kulkarni

  • 1Department of Pharmacology, Seth G S Medical College and KEM Hospital, Parel, Bombay, India.

Journal of Tropical Pediatrics
|March 1, 1991
PubMed
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Measles infection impairs immune cells like polymorphonuclear cells (PMN) and monocytes, increasing susceptibility to bacterial infections. This study confirms depressed immune cell function in children with measles, impacting their ability to fight secondary infections.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pediatrics

Background:

  • Immune suppression during measles infection is a long-recognized clinical observation.
  • Acute bacterial infections are a primary cause of severe illness and death in measles patients.

Purpose of the Study:

  • To investigate the impact of measles on the phagocytic and bactericidal/fungicidal functions of polymorphonuclear cells (PMN) and monocytes.
  • To compare immune cell function in children with measles and secondary bacterial infections versus those with bacterial infections alone.

Main Methods:

  • Compared phagocytic and bactericidal/fungicidal capacities of PMN and monocytes in 14 children with measles against 25 healthy controls.
  • Assessed immune cell activation in 7 children with measles and bacterial infections, comparing them to 11 children with bacterial infections but no measles.

Related Experiment Videos

  • Measured serum immunoglobulin levels.

    • Main Results:

    • Children with measles showed significantly depressed PMN and monocyte function compared to healthy controls.
    • PMN in measles patients with bacterial infections did not reach the expected activated state.
    • Serum immunoglobulin levels remained unaltered in measles patients.
    • Peripheral blood monocyte functions were also found to be depressed in measles.

    Conclusions:

    • Measles infection significantly impairs both PMN and monocyte immune functions.
    • This immune dysfunction in measles contributes to the high incidence of severe secondary bacterial infections.
    • Further research into immune modulation during measles is warranted to improve patient outcomes.