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Differential regulation of estrogen-dependent sexual development of rat brain by growth factors
N Hasegawa1, T Takeo, Y Sakuma
1Department of Physiology I, Hirosaki University School of Medicine, Japan.
Neuroscience Letters
|February 25, 1991
Abstract:
Intraventricular infusion of antiserum to nerve growth factor (ANGF), but not that to insulin, epidermal growth factor nor normal rabbit serum, resisted estrogen-induced behavioral defeminization in the female rat neonates. A significant number of the ANGF-treated rats showed lordosis as adults despite neonatal estrogen, but positive feedback of estrogen on serum luteinizing hormone was absent. Sexual phenotype in behavioral and gonadotropic functions may be under differential development regulation.