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Subpial beta/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia
H Yamaguchi1, Y Nakazato, T Yamazaki
1College of Medical Care and Technology, Gunma University, Japan.
Neuroscience Letters
|February 25, 1991
Abstract:
We examined the ultrastructure of subpial beta/A4 amyloid deposits in the brains of patients with Alzheimer-type dementia. A few amyloid fibrils were found between thick astroglial processes (glia limitans). We also examined the ultrastructural localization of beta/A4 protein by the indirect immunoperoxidase technique. Electron-dense immunoreactive products scattered sporadically in the subpial areas were observed between astroglial processes. The labeling was fibrillar and/or amorphous. Subpial beta/A4 deposition may occur between astroglial processes as amorphous pre-amyloid and amyloid fibrils.