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Experimental observations on the effects of the nitrogen mustards on neoplastic tissues

D A KARNOFSKY, J H BURCHENAL

    Cancer Research
    |March 19, 2010
    PubMed
    Abstract

    No abstract available in PubMed .

    Keywords:
    CHLOROETHYLAMINES/effects

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    2° Amines to N-Nitrosamines: Reaction with NaNO201:20

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    Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.

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