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[SPECT with 99m-TC HM PAO in the study of classical hemicrania]
S Tomaiolo1, F Stiglich, F Bonomo
1Medicina Nucleare e Radioterapia, Ospedale Civile, Sondrio.
La Radiologia Medica
|April 1, 1991
Summary
Single Photon Emission Tomography (SPECT) with 99mTc-HM PAO effectively detects diffuse cortical hypoperfusion during migraine attacks. This reliable imaging technique aids in diagnosing suspected migraine cases, offering reproducible results.
Area of Science:
- Neurology
- Nuclear Medicine
- Radiology
Background:
- Migraine attacks present diagnostic challenges.
- Neuroimaging plays a crucial role in understanding migraine pathophysiology.
Purpose of the Study:
- To evaluate the utility of Single Photon Emission Tomography (SPECT) with 99mTc-HM PAO in diagnosing migraine attacks.
- To assess the correlation between clinical presentation and neuroimaging findings in migraine patients.
Main Methods:
- Five patients with migraine attacks underwent Electroencephalography (EEG), Computed Tomography (CT), and SPECT with 99mTc-HM PAO.
- EEG and SPECT were repeated during the interictal period for comparison.
Main Results:
- All patients exhibited diffuse cortical hypoperfusion on SPECT during migraine attacks.
- EEG showed non-specific abnormalities in two patients; CT scans were normal in all.
- A strong correlation was observed between clinical migraine symptoms and hemispheric impairment on SPECT.
Conclusions:
- SPECT with 99mTc-HM PAO is a reliable and reproducible imaging modality for diagnosing suspected migraine attacks.
- The technique can be readily implemented in nuclear medicine centers with modern gamma cameras.